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What is the best treatment for head and neck cancer? Surgical removal of the tumor is often used to treat head and neck cancers. It may be used alone or in combination with radiation therapy and chemotherapy. In some cases, nearby lymph nodes are removed as part of treatment. Radiation therapy. Head and neck cancers include cancers in the larynx, throat, lips, mouth, nose, salivary glands. Tobacco, heavy alcohol use & infection with human papillomavirus (HPV) increase the risk of head and neck cancers.